The behavior of the 2006 ten Tusscher-Panfilov model of human ventricular myocytes under\nthe impact of periodic excitation impulses was studied in the BeatBox simulation environment.\nThe cardiomyocyte model has a limited susceptibility to an forced higher frequency\nexcitation rhythm. A high-frequency excitation rhythm can be forced by gradually\nincreasing the frequency of excitation impulses. The mechanism of defibrillation pulse impact\nconsists of presumably prolonging the refractoriness of cardiomyocytes which undermines\ntheir susceptibility for a long time to a forced high-frequency rhythm of fibrillation,\nas a result for which they hinder the propagation of a fibrillation wave. This is the only\nmechanism of defibrillation that was identified during the simulation. The threshold energy\nof a depolarizing defibrillation pulse prolonging the refractoriness of the cardiomyocyte varies\ndepending on a delay relative to the excitation impulse (the excitation cycle phase) in a\nwide range (the maximum value exceeds the minimum by several thousand times). The results\nshow differences in the mechanisms of impact on a cardiomyocyte between an excitation\nimpulse and a monophasic defibrillation pulse.
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